[BioSB] Kappa – RPab

[BioSB] Kappa – RPab

 

Catalog No.	Antibody Type	Dilution	Volume/QTY
BSB 3086	Prediluted	Ready-To-Use*	3.0 ml
BSB 3087	Prediluted	Ready-To-Use*	7.0 ml
BSB 3088	Prediluted	Ready-To-Use*	15.0 ml
BSB 3089	Concentrated	1:500 / 1:5	0.1 ml
BSB 3090	Concentrated	1:500 / 1:5	0.5 ml
BSB 3091	Concentrated	1:500 / 1:5	1.0 ml
BSB 3688	Control Slides	5

Intended Use	For In Vitro Diagnostic Use. This antibody is intended for use in Immunohistochemical (IHC) and Immunofluorescence (IF) applications on formalin-fixed paraffin-embedded tissues (FFPE), frozen tissue sections and cell preparations. Interpretation of results should be performed by a qualified medical professional.
Summary and Explanation	Kappa detects surface immunoglobulin on normal and neoplastic B-cells. In paraffin-embedded tissue, Kappa exhibits strong staining of kappa-positive plasma cells and cells that have absorbed exogenous immunoglobulin.   When studying B-cell neoplasms, the determination of light-chain ratios remains the centerpiece. This is sound reasoning because most B-cell Lymphomas express either Kappa or Lambda light chains, whereas reactive proliferations display a mixture of Kappa and Lambda-positive cells. If only a single light-chain type is detected, a lympho-proliferative disorder is very likely. Monoclonality is determined by a Kappa-Lambda ratio greater than or equal to 3:1, a Lambda-Kappa ratio greater than or equal to 2:1, or a monoclonal population of 75% or more of the total population. In IgG-dominant immune complex-mediated glomerulonephritis, there are multiple pathological findings that strongly suggest the diagnosis of Lupus Nephritis including immunofluorescence staining for IgG, IgM, IgA, Kappa or Lambda, C3 and C1.
Antibody Type	Rabbit Polyclonal	Clone	Polyclonal
Isotype	IgG	Reactivity	Paraffin, Frozen
Localization	Cytoplasmic	Control	Tonsil, Lymph Node
Presentation	Kappa is a purified immunoglobulin fraction of rabbit antiserum that is filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.