[Leading Biology] Recombinant Mouse FGF2 Protein(N-His Tag)

[Leading Biology] Recombinant Mouse FGF2 Protein(N-His Tag)

 

 

 

PM0105E3-20μg

PM0105E3-100ug

Recombinant Mouse FGF2 Protein(N-His Tag)

Brand	Leading Biology	Catalog Number	PM0105E3
Product Type	Cytokine	Field of Research

 

Nature	Recombinant Protein
Expression Host	E.coli
Species	Mouse
AA Sequence	NP_032032.1(Ala11-Ser154)
Tags	N-His
Molecular Weight	18KD
Activity	Measured in a cell proliferation assay using NR6R-3T3 mouse fibroblast cells.
Form	lyophilized
Purity	Greater than 95% by SDS-PAGE
Storage & Stability	-70°C
Storage Buffer	0.2 μm filtered PBS, pH7.4
Product Description	FGF2, also known as basic fibroblast growth factor (bFGF) and FGF-β, is a growth factor and signaling protein encoded by the FGF2 gene. It is synthesized primarily as a 155 amino acid polypeptide, resulting in an 18 kDa protein. However, there are four alternate start codons which provide N-terminal extensions of 41, 46, 55, or 133 amino acids, resulting in proteins of 22 kDa (196 aa total), 22.5 kDa (201 aa total), 24 kDa (210 aa total) and 34 kDa (288 aa total), respectively. Generally, the 155 aa/18 kDa low molecular weight (LMW) form is considered cytoplasmic and can be secreted from the cell, whereas the high molecular weight (HMW) forms are directed to the cell’s nucleus. Fibroblast growth factor protein was first purified in 1975, but soon afterwards others using different conditions isolated basic FGF, Heparin-binding growth factor-2, and Endothelial cell growth factor-2. Gene sequencing revealed that this group was in fact the same FGF2 protein and that it was a member of a family of FGF proteins. FGF2 binds to and exerts effects via specific fibroblast growth factor receptor (FGFR) proteins which themselves constitute a family of closely related molecules.
Synonyms	bFGF Protein(Mouse); Fgf-2 Protein(Mouse); Fgfb Protein(Mouse)