[CTK Biotech] Mouse Anti-Pan Dengue NS1 Monoclonal Antibody

[CTK Biotech] Mouse Anti-Pan Dengue NS1 Monoclonal Antibody

 

Physical                                                 Liquid

Concentration                           ≥ 2 mg/mL by OD280 nm

Storage Buffer                           D-PBS, pH 7.2-7.4

Preservatives                              0.099% NaN3

Purity                                                           ≥ 95% on 12.5% SDS-PAGE

Purification                                      Protein A affinity chromatography

Application                                      Coating or conjugate antibody in ELISA, ICT.   Pairing with B7060.

Cross Reactivity                     No reactivity with Zika virus NS1

Dengue virus (DENV) is a single positive strand RNA virus of the Flaviviridae family and a causative agent of the infectious tropical disease Dengue Fever. There are four serotypes of the virus, DENV-1, DENV-2, DENV-3 and DENV-4.

Dengue NS1 (Non-Structural protein 1) is a versatile glycoprotein of the dengue virus that is secreted as a hexamer, binds to the cell surface, and has immune evasive functions. Dengue virus NS1 antigen is also used as an early detection marker (days 1 to 9 after onset) for dengue virus infection.

B7050 was generated by immunizing mice with recombinant DENV-2 NS1 expressed by human cells and purified from ascites via protein A affinity chromatography. It recognizes all 4 types of DENV NS1 in an order as:  DN2=DN3> DN4> DN1.