[Signalway Antibody - SAB] Mouse Anti-Human CD366(Tim-3) mAb #P1067

[Signalway Antibody - SAB] Mouse Anti-Human CD366(Tim-3) mAb #P1067

 

• Product NameMouse Anti-Human CD366(Tim-3) mAb
• Host SpeciesMouse
• ClonalityMonoclonal
• Clone No.3H4
• IsotypeMouse IgG1, κ
• ApplicationsIHC
• Species ReactivityHu
• Immunogen DescriptionHuman Tim-3 fusion protein
• Alternative Names   
• Formulation Lyophilized from a 0.2μm filtered solution in phosphate buffered saline (PBS) and reconstitute with sterile PBS .
• Storage Store protected from light at 2-8˚C. Do not freeze. The expiration date is indicated on the vial label.

• Preparation:This antibody was produced from a hybridoma. IgG1 fraction of culture supernatant from the hybridoma was purified by protein G affinity chromatography.
  Product Notices:This reagent has been pre-diluted for use at the recommended Volume per Test. We typically use 1 10^6 cells in a 100-?l experimental sample (per test). An isotype control should be used at the same concentration as the antibody of interest.

• CD366 (Tim-3) is a transmembrane protein also known as T cell immunoglobulin and mucin domain containing protein-3. Tim-3 is expressed at high levels on activated T cells (preferentially on Th1 cells, monocytes/macrophages, and dendritic cells). Tim-3 has also been shown to exist as a soluble protein. Cells expressing Tim-3 are present at high levels in the CNS of animals at the onset of experimental autoimmune encephalomyelitis (EAE), a disease mediated by lymphocytes secreting Th1-like cytokines. Tim-3 has been proposed to inhibit Th1-mediated immune responses and promote immunological tolerance.