[TaiClone] Elagolix sodium
tcsc0003317
Specifications
Purity / Grade
>98%
Solubility
10 mM in DMSO
Smiles
smiles
Misc Information
Alternative Names
NBI-56418 sodium
Observed Molecular Weight
653.57
Product Description
Elagolix sodium is a human GnRH receptor (GnRHR) antagonist with an IC50 and Ki of 0.25 and 3.7 nM, respectively.
IC50 & Target: IC50: 0.25 nM (GnRHR)[1]
Ki: 3.7 nM (GnRHR)[2]
In Vitro: Elagolix sodium is a human GnRH receptor (GnRHR) antagonist with an IC50 of 0.25 nM in Kinase assay. Elagolix sodium has advanced to phase 3 trials for the treatment of endometriosis and uterine fibroids. Elagolix sodium also shows NFAT inhibition with an IC50 of 5.4 nM and effectively blocks Ca2+ flux with an IC50 of 0.86 nM[1]. Kinase assay also demonstrates that Elagolix sodium is a human GnRH receptor (GnRHR) antagonist with a Ki value of 3.7 nM[2].
Information
CAS No
832720-36-2
Formula
C32H29F5N3NaO5
Clinical Information
clinical
information
Pathway
GPCR/G Protein
Target
GNRH Receptor
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