[Zeta Corperation] SOX10 Monoclonal Antibody IVD

[Zeta Corperation] SOX10 Monoclonal Antibody IVD

 

Anti-mouse: clone ZM10, Cat # Z2293

 

"Sry-related HMG box (SOX) genes encode a key group of transcription factors. SOX-10 plays an important role in the late stage of neural crest formation, maintenance of multipotency of neural crest cells as a stem cell, and specification of derivative cell fates to schwannian and melanocytic destination. In normal tissue, SOX-10 is expressed in Schwann cells, melanocytes, and myoepithelial cells of salivary and breast glands. It is also expressed in neural crest-derived tumors, including various types of malignant melanoma, clear cell sarcoma, neuroblastoma, schwannoma, and malignant nerve sheath tumor. In comparison to other markers, SOX-10 is especially sensitive for desmoplastic and spindle cell malignant melanomas. In nonmelanocytic tumors, SOX-10 stains more carcinoid tumors, nerve sheath tumors, myoepithelial tumors, and sustentacular cells of pheochromocytomas and paragangliomas.