[BeCytes Biotechnology] Plateable Primary Human Hepatocytes (Cryo)

[BeCytes Biotechnology] Plateable Primary Human Hepatocytes (Cryo)

 

 

 

HuHECP	Plateable
HuHECP-30	Plateable & 3D Certified
HuHECPMI	Plateable - Metabolism & Induction Certified
HuHECPMI-3D	Plateable – Metabolism, Induction Certified & 3D Qualified

 

Primary Plateable Hepatocytes Characterization

Basic Characterization

• Cell number and viability after thawing
• Optimal seeding density (24 and 96-well plate)
• Adhesion capacity
• Morphology of the cells in culture
• Ability to generate spheroids
• Number of days the cells are in culture

Advanced Characterization

• Induction assays testing the ability of cytochromes to overexpress.
• Metabolisation assays in which the resulting metabolites shall be detected and quantified.
• WGS genotyping from our lots included.

 

Common Uses

• Metabolism analysis
• Toxicity assessments
• Enzyme activity studies
• Prediction of metabolic clearance
• Drug-drug interaction assays
• Hepatotoxicity
• Among Others

 

Plateable hepatocytes are characterized by their ability to adhere and form a confluent monolayer on culture dishes or plates coated with extracellular matrix proteins like collagen. This adherence property makes them particularly valuable when researchers need a well-differentiated hepatocyte model to study long-term liver functions. They are often employed in assays related to drug metabolism, toxicity testing, and liver-specific disease modeling.

These hepatocytes (Plateable Hepatocytes) are considered the preferred choice for determining the metabolic stability and metabolism of new compounds in development