[Leading Biology] Recombinant Human FGL1 Protein
PH0005E1
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Brand
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Leading Biology
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Catalog Number
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PH0005E1
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Product Type
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Recombinant Protein
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Field of Research
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Nature
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Recombinant Protein
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Expression Host
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E.coli
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Species
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Human
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AA Sequence
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NP_004458.3 (Leu 23-Ile 312)
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Molecular Weight
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35 KD
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Activity
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Measured by its ability to bind biotinylated LAG3 domain1/2 in functional ELISA.
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Form
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Liquid
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Concentration
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0.6mg/mL
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Purity
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Greater than 95% by SDS-PAGE
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Storage & Stability
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-70ºC
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Storage Buffer
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0.2 μm filtered PBS, pH7.4
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Product Description
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Fibrinogen-like protein 1 (FGL1), a liver-secreted protein, is a major LAG-3 functional ligand independent from MHC-II. FGL1 inhibits antigen-specific T cell activation, and ablation of FGL1 in mice promotes T cell immunity. Blockade of the FGL1-LAG-3 interaction by monoclonal antibodies stimulates tumor immunity and is therapeutic against established mouse tumors in a receptor-ligand inter-dependent manner.
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Synonyms
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Fibrinogen-like protein 1 (human), HFREP1 Protein, Human; HP-041 Protein, Human; LFIRE-1 Protein, Human; LFIRE1 Protein, Human
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