[German Research Products – GRP] MDM2 antibody
Catalog Number: GRP9
| MDM2 antibody |
| GRP9 |
| Rabbit |
| Human, Mouse |
| Unconjugated |
| ChIP, ICC, IF, IHC-P, IP, WB |
| Recombinant protein encompassing a sequence within the center region of human MDM2. The exact sequence is proprietary. |
| Liquid: 1XPBS, 20% Glycerol (pH7). 0.025% ProClin 300 was added as a preservative. |
| 0.76 mg/ml |
| Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles. |
| For research use only. |
| IgG |
| Polyclonal |
| Purified by antigen-affinity chromatography. |
| Q00987 |
| 4193 |
This gene is a target gene of the transcription factor tumor protein p53. The encoded protein is a nuclear phosphoprotein that binds and inhibits transactivation by tumor protein p53, as part of an autoregulatory negative feedback loop. Overexpression of this gene can result in excessive inactivation of tumor protein p53, diminishing its tumor suppressor function. This protein has E3 ubiquitin ligase activity, which targets tumor protein p53 for proteasomal degradation. This protein also affects the cell cycle, apoptosis, and tumorigenesis through interactions with other proteins, including retinoblastoma 1 and ribosomal protein L5. More than 40 different alternatively spliced transcript variants have been isolated from both tumor and normal tissues. [provided by RefSeq]
