[ELK Biotech] Claudin-2 (8H11) Mouse mAb

[ELK Biotech] Claudin-2 (8H11) Mouse mAb

 

 

Catalog No. : EM1403

Product name： Claudin-2 (8H11) Mouse mAb Source： Mouse Applications： WB, IHC Species reactivity： Human,Rat,Mouse Recommended dilutions： WB 1:1,000-2,000   IHC:1;100-1:200 Immunogen： Synthetic Peptide Specificity： Human Storage： PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles. Clonality： Monoclonal Isotype： IgG1 Concentration： 1mg/ml Observed band： 25kDa GeneID（Human）： 9075 Human Swiss-Prot No.： P57739 Cellular localization： Cell junction,tight junction,Cell membrane Background： The claudin family is composed of 23 integral membrane proteins, and their expression, which varies among tissue types, may determine both the strength and properties of the epithelial barrier. Alteration in claudin protein expression pattern is associated with several types of cancer . Claudin-2 is expressed primarily in the proximal tubule of the normal mammalian kidney, where it regulates transepithelial ion (e.g., Na+, Cl-) reabsorption . Increased expression of Claudin-2 has been reported in some cancer cell lines , including A549 lung adenocarcinoma cells, where its nuclear distribution was positively associated with enhanced proliferation .