[OraganaBio] Peripheral Blood Mononuclear Cells (Crohn’s Disease)

[OraganaBio] Peripheral Blood Mononuclear Cells (Crohn’s Disease)

 

D-PBMC-CD-050

 

PBMCs from Crohn’s disease donors, isolated from leukopak material under cGMP-aligned conditions. Sourced from OrganaBio’s qualified, recallable donor pool with 14-marker infectious disease screening per 21 CFR 1271 and high-resolution NGS HLA typing. Disease-state PBMCs are supplied for research/discovery use only. Best fit: Th1/Th17 profiling, anti-TNF and JAK inhibitor mechanism-of-action work, and IBD comparative immunology.

 

 

LeukoPAC-D-PBMC – Disease-State Cryopreserved Peripheral Blood Mononuclear Cells

 

 

 

LeukoPAC-D-PBMC delivers cryopreserved peripheral blood mononuclear cells from donors with documented disease conditions, collected under IRB-approved protocols. Disease-state PBMCs are essential for cell therapy development because manufacturing processes and assays optimized using healthy donor cells frequently fail to translate to cells from patients in the target population.

Crohn’s disease donor PBMCs carry the Th1/Th17 skew and gut-homing lymphocyte phenotype relevant to intestinal inflammation research and IBD drug mechanism studies.

 

 

Why Disease-State PBMCs

Patients eligible for cell therapies have often been treated with multiple rounds of chemotherapy or other interventions, which can compromise T cell functionality and shift cellular phenotypes in ways that healthy donor controls do not capture. Process development on disease-state PBMCs allows manufacturing teams and assay developers to validate workflows against material that reflects the immune biology of the patient population they intend to treat.

 

 

Available Indications

This product is sourced from donors with documented Crohn’s disease. OrganaBio’s disease-state donor pool spans 24 autoimmune and chronic inflammatory indications including systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, type 1 diabetes, Crohn’s disease, ulcerative colitis, psoriasis, and others. Contact the scientific team to confirm availability and lot status for your specific indication.

 

 

Documentation

Each sample is supported by comprehensive documentation including disease history, treatment background, inclusion and exclusion criteria compliance, and demographic profiles. Every lot ships with documentation. Donors are enrolled under IRB-approved protocols with verified clinical diagnosis.

 

 

Configuration

Standard configuration: 1.0×10⁷ cells per vial, cryopreserved, stored at <−150°C in liquid nitrogen vapor phase. Custom cell counts, fresh format, and specific donor criteria available on request. Cells are for preclinical research use only and not for use in humans.

For background on disease-state donor samples in cell therapy development, see Why Disease-State Donor Samples Are Essential for Cell Therapy Development.