[Zeta Corporation] AMACR

[Zeta Corporation] AMACR

 

Classification

IVD

Catalogue Number

Z2001RL

 

 

Species Reactivity:

Humans; others not tested

 

Known Applications:

Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)

 

Supplied As:

Buffer with protein carrier and preservative

 

Storage:

Store at 2ºC to 8ºC

 

Control:

Prostate carcinoma

 

Visualization:

Cytoplasmic

 

Isotype:

IgG

 

Immunogen:

Human AMACR (P504S) polypeptide

 

 

 

13H4RabbitMonoclonal

AMACR (P504S) is an essential enzyme in the b-oxidation of branched-chain fatty acids. Recently, AMACR (P504S) was identified through cDNA library subtraction and microarrays in malignant prostate tissues. High expression of AMACR (P504S) protein is found in prostatic adenocarcinoma but not in benign prostatic tissue by immunohistochemical staining in paraffin-embedded tissues. The expression of AMACR (P504S) is also detected in two premalignant lesions of the prostate: high-grade prostatic intraepithelial neoplasia (PIN) and atypical adenomatous hyperplasia. Using AMACR (P504S) as a positive marker along with basal cell staining (34bE12 or P63) as a negative marker could help to confirm the diagnosis of small focus of prostate carcinoma on needle biopsy.