[Cytes Biotechnology] Primary Human Hepatic Stellate Cells

[Cytes Biotechnology] Primary Human Hepatic Stellate Cells

 

 

 

 

HuSC-P1	Stellate cells, passage 1	100.000 500.000
HuSC-P2	Stellate cells, passage 2	100.000 500.000
HuSC-P3	Stellate cells, passage 3	100.000 500.000
HuSCP	Plated Stellate cells	1 plate

 

Human Hepatic stellate cells Charaterization

• Charaterization I
  • Cell number and viability after thawing
    Morphological analysis of cells over time

• Charaterization II
  Cytes Biotechnology uses key antibodies by immunofluorescence to characterize stellate cells showing their expression at the quiescent and activated state of the cells.

 

Common Uses

Cell Based Assays

• Toxicity
• Drug screening
• Metabolism

Useful tool to study

• Liver function
• Physiology
• Liver diseases (Fibrotic Models)

 

 

Human hepatic stellate cells have the ability to switch to their activated phase and transdifferentiate into myofibroblast-like cells, which are involved in the pathogenesis of liver fibrosis.

In addition, activated stellate cells can proliferate, contract and regulate chemotaxis, becoming the main source of extracellular matrix production during liver injury.

extracellular matrix production during liver injury. This leads to collagen secretion that provides a scaffold for hepatocytes to repopulate during tissue regeneration and can lead to cirrhosis.