[Genomeme] EZH2

[Genomeme] EZH2

CAT. NO. IHC570-7

 

CLONE:
IHC570

ISOTYPE:
IgG1

HOST SPECIES:
Mouse

CLONALITY:
Monoclonal

POSITIVE CONTROL:
Prostate Adenocarcinoma, Tonsil, Breast Carcinoma

DILUTION RANGE:


INTENDED USE/REG. STATUS:
IVDR

 

Enhancer of Zeste Homolog 2 (EZH2) is a methylase of histone H3 that silences gene expression in those regions. EZH2 is overexpressed or mutated in gastric, prostate, uterine, breast, and renal cell cancers, as well as in melanoma and most B- and T-cell lymphomas. Although EZH2 is usually present in follicular centers, it is not expressed in the mantle zones, plasma cells, follicular or interfollicular T-lymphocytes, natural killer T-lymphocytes, plasmacytoma, lymphoplasmacytic lymphoma, or MALT lymphoma. EZH2 is rarely present in normal breast duct epithelium and in normal and hyperplastic lymph node. Anti-EZH2 is also useful for detecting lymphoma and non-small cell lung cancers. EZH2 is associated with tumour proliferation and can be used in staining panels to distinguish aggressive lymphomas from less aggressive lymphomas or normal cells.